AKT -> mTOR pertuzumab -> mTOR mTOR -> mTOR trastuzumab -| ERBB2 pertuzumab -| ERBB2 ERBB3 -> ERBB2 EGF -> ERBB2 ERBB2 -> ERBB2 erlotinib -| ERBB2 PLCg -> PKCa PKCa -> PKCa ERBB1 -> PLCg ERBB3 -> PLCg PLCg -> PLCg EGF -> PLCg ERBB2 -> PLCg AKT -> p70S6K ERK1_2 -> p70S6K mTOR -> p70S6K p70S6K -> p70S6K pertuzumab -| ERBB3 ERBB3 -> ERBB3 erlotinib -| ERBB3 HRG -> ERBB3 AKT -> AKT PDK1 -> AKT ERBB3 -> AKT mTOR -> AKT ERBB1 -> ERBB1 pertuzumab -| ERBB1 PLCg -> ERBB1 EGF -> ERBB1 erlotinib -| ERBB1 PDK1 -> PDK1 ERBB1 -> PDK1 ERBB3 -> PDK1 MEK1_2 -> PDK1 ERBB2 -> PDK1 ERBB1 -> MEK1_2 ERBB3 -> MEK1_2 MEK1_2 -> MEK1_2 ERBB2 -> MEK1_2 pertuzumab -> ERK1_2 ERK1_2 -> ERK1_2 EGF -> ERK1_2 MEK1_2 -> ERK1_2 $AKT: (((AKT | ERBB3) | PDK1) | mTOR) $ERBB1: (((ERBB1 & !(pertuzumab | erlotinib)) | (EGF & !(pertuzumab | erlotinib))) | (PLCg & !(pertuzumab | erlotinib))) $ERBB2: (((EGF & !((trastuzumab | pertuzumab) | erlotinib)) | (ERBB2 & !((trastuzumab | pertuzumab) | erlotinib))) | (ERBB3 & !((trastuzumab | pertuzumab) | erlotinib))) $ERBB3: ((ERBB3 & !((erlotinib | pertuzumab) | pertuzumab)) | (HRG & !((erlotinib | pertuzumab) | pertuzumab))) $ERK1_2: (((ERK1_2 | EGF) | pertuzumab) | MEK1_2) $MEK1_2: (((ERBB1 | ERBB3) | ERBB2) | MEK1_2) $PDK1: ((((ERBB1 | MEK1_2) | ERBB3) | ERBB2) | PDK1) $PKCa: (PLCg | PKCa) $PLCg: ((((ERBB3 | PLCg) | ERBB2) | ERBB1) | EGF) $mTOR: ((pertuzumab | mTOR) | AKT) $p70S6K: (((AKT | p70S6K) | ERK1_2) | mTOR)